Drug interactions
Azilsartan-chlorthalidone + Parecoxib
Severity: Moderate
Azilsartan-chlorthalidone and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, converted to the COX-2 inhibitor valdecoxib, can reduce the antihypertensive effect of ARBs and diuretics and impair renal function. In volume-depleted or elderly patients the combination may cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Azilsartan-chlorthalidone and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition reduces renal prostaglandin synthesis, causing sodium retention and reduced renal perfusion that opposes ARB and diuretic effects.
What to do
Use the lowest effective dose for the shortest time and ensure adequate hydration. Monitor blood pressure, serum creatinine, and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Parecoxib?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, converted to the COX-2 inhibitor valdecoxib, can reduce the antihypertensive effect of ARBs and diuretics and impair renal function. In volume-depleted or elderly patients the combination may cause acute kidney injury and hyperkalemia.
How serious is the interaction between Azilsartan-chlorthalidone and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose for the shortest time and ensure adequate hydration. Monitor blood pressure, serum creatinine, and potassium.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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