Drug interactions
Azilsartan-chlorthalidone + Pirbuterol
Severity: Moderate
Azilsartan-chlorthalidone and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirbuterol is a beta-2 agonist that can reduce serum potassium, and chlorthalidone also causes renal potassium loss. Combined use may cause clinically relevant hypokalemia and raise arrhythmia risk, especially with high doses.
What this interaction means in plain words
Azilsartan-chlorthalidone and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 mediated cellular potassium uptake and diuretic renal potassium wasting.
What to do
Monitor serum potassium and magnesium, especially with frequent bronchodilator use. Supplement as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Pirbuterol?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirbuterol is a beta-2 agonist that can reduce serum potassium, and chlorthalidone also causes renal potassium loss. Combined use may cause clinically relevant hypokalemia and raise arrhythmia risk, especially with high doses.
How serious is the interaction between Azilsartan-chlorthalidone and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, especially with frequent bronchodilator use. Supplement as needed.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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