Drug interactions
Azilsartan-chlorthalidone + Sacubitril / valsartan
Severity: Major
Azilsartan-chlorthalidone and Sacubitril / valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril/valsartan contains an ARB, so combining it with azilsartan results in dual angiotensin receptor blockade. This increases the risk of hypotension, hyperkalemia, and renal impairment without clear benefit.
What this interaction means in plain words
Azilsartan-chlorthalidone and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate angiotensin II receptor blockade leading to additive hypotension, reduced aldosterone effect, and renal hemodynamic changes.
What to do
Avoid combining two ARB-containing products and select one agent. If switching, stop azilsartan-chlorthalidone before starting sacubitril/valsartan and monitor blood pressure, potassium, and creatinine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Sacubitril / valsartan?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sacubitril/valsartan contains an ARB, so combining it with azilsartan results in dual angiotensin receptor blockade. This increases the risk of hypotension, hyperkalemia, and renal impairment without clear benefit.
How serious is the interaction between Azilsartan-chlorthalidone and Sacubitril / valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ARB-containing products and select one agent. If switching, stop azilsartan-chlorthalidone before starting sacubitril/valsartan and monitor blood pressure, potassium, and creatinine.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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