Drug interactions
Azilsartan-chlorthalidone + Salsalate
Severity: Moderate
Azilsartan-chlorthalidone and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a salicylate NSAID, can blunt the blood pressure lowering effect of the azilsartan and chlorthalidone combination. In patients who are older, volume depleted or have existing renal impairment, the combination can also reduce kidney function and may cause acute kidney injury.
What this interaction means in plain words
Azilsartan-chlorthalidone and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis causes sodium and water retention and reduced renal perfusion, opposing diuretic and angiotensin receptor blocker effects and adding to renal hemodynamic stress.
What to do
Monitor blood pressure and serum creatinine and potassium when starting or changing salsalate, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic where renal risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Salsalate?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, a salicylate NSAID, can blunt the blood pressure lowering effect of the azilsartan and chlorthalidone combination. In patients who are older, volume depleted or have existing renal impairment, the combination can also reduce kidney function and may cause acute kidney injury.
How serious is the interaction between Azilsartan-chlorthalidone and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum creatinine and potassium when starting or changing salsalate, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic where renal risk is high.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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