Drug interactions
Azilsartan-chlorthalidone + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Azilsartan-chlorthalidone and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations can cause fluid loss and electrolyte shifts. Combined with a thiazide-like diuretic and an angiotensin receptor blocker, this raises the risk of dehydration, acute kidney injury, and electrolyte disturbances such as hyponatremia or potassium changes, which may lead to arrhythmias or seizures.
What this interaction means in plain words
Azilsartan-chlorthalidone and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive volume depletion and electrolyte disturbance from bowel cleansing together with diuretic effects, and reduced renal perfusion autoregulation under angiotensin receptor blockade.
What to do
Ensure good hydration during bowel preparation and consider holding the diuretic and ARB on the day of the preparation in at-risk patients. Check electrolytes and renal function beforehand in patients with kidney disease or other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azilsartan-chlorthalidone and Sodium sulfate / ?magnesium sulfate / potassium chloride, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osmotic bowel preparations can cause fluid loss and electrolyte shifts. Combined with a thiazide-like diuretic and an angiotensin receptor blocker, this raises the risk of dehydration, acute kidney injury, and electrolyte disturbances such as hyponatremia or potassium changes, which may lead to arrhythmias or seizures.
How serious is the interaction between Azilsartan-chlorthalidone and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure good hydration during bowel preparation and consider holding the diuretic and ARB on the day of the preparation in at-risk patients. Check electrolytes and renal function beforehand in patients with kidney disease or other risk factors.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
