Drug interactions
Azilsartan-chlorthalidone + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Azilsartan-chlorthalidone and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparation causes fluid and electrolyte losses, and chlorthalidone adds potassium and sodium depletion. Combined with an ARB, dehydration may cause acute kidney injury.
What this interaction means in plain words
Azilsartan-chlorthalidone and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive fluid and electrolyte loss from diuretic and osmotic bowel cleansing, with ARB-related reduced renal perfusion tolerance.
What to do
Consider withholding the diuretic and ARB on the day of preparation, ensure hydration, and check electrolytes and creatinine in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparation causes fluid and electrolyte losses, and chlorthalidone adds potassium and sodium depletion. Combined with an ARB, dehydration may cause acute kidney injury.
How serious is the interaction between Azilsartan-chlorthalidone and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding the diuretic and ARB on the day of preparation, ensure hydration, and check electrolytes and creatinine in high-risk patients.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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