Drug interactions
Azilsartan-chlorthalidone + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Azilsartan-chlorthalidone and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel preparations cause fluid and electrolyte losses. Together with chlorthalidone and azilsartan, the risk of dehydration, acute kidney injury, and electrolyte abnormalities is increased, with potential for arrhythmias or seizures.
What this interaction means in plain words
Azilsartan-chlorthalidone and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive volume depletion and electrolyte disturbance from bowel cleansing together with diuretic effects, and reduced renal perfusion autoregulation under angiotensin receptor blockade.
What to do
Maintain adequate fluid intake and consider temporarily withholding the diuretic and ARB around the preparation in patients at risk. Check electrolytes and renal function in patients with kidney disease or the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel preparations cause fluid and electrolyte losses. Together with chlorthalidone and azilsartan, the risk of dehydration, acute kidney injury, and electrolyte abnormalities is increased, with potential for arrhythmias or seizures.
How serious is the interaction between Azilsartan-chlorthalidone and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain adequate fluid intake and consider temporarily withholding the diuretic and ARB around the preparation in patients at risk. Check electrolytes and renal function in patients with kidney disease or the elderly.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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