Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan
Severity: Contraindicated
Amlodipine-olmesartan-hydrochlorothiazide and Sparsentan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan also blocks the angiotensin II receptor, so adding olmesartan duplicates this action. This raises the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
Why it happens
Additive pharmacodynamic angiotensin II type 1 receptor blockade.
What to do
Do not combine; stop the ARB-containing product before starting sparsentan.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amiloride + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
- Azilsartan + Sparsentan Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Sparsentan?
MediHelp rates the interaction as contraindicated. Amlodipine-olmesartan-hydrochlorothiazide and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan also blocks the angiotensin II receptor, so adding olmesartan duplicates this action. This raises the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop the ARB-containing product before starting sparsentan.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Acemetacin. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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