Drug interactions
Azilsartan-chlorthalidone + Squill
Severity: Major
Azilsartan-chlorthalidone and Squill: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Squill has digitalis-like cardiac glycoside activity, and potassium loss from chlorthalidone can increase its arrhythmogenic toxicity. Azilsartan may partly offset potassium loss, but the risk remains.
What this interaction means in plain words
Azilsartan-chlorthalidone and Squill can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Diuretic-induced hypokalemia and hypomagnesemia sensitize the myocardium to glycoside toxicity.
What to do
Avoid the combination where possible. If used, monitor potassium, magnesium and ECG regularly and correct deficits.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Squill?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Squill can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Squill has digitalis-like cardiac glycoside activity, and potassium loss from chlorthalidone can increase its arrhythmogenic toxicity. Azilsartan may partly offset potassium loss, but the risk remains.
How serious is the interaction between Azilsartan-chlorthalidone and Squill?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor potassium, magnesium and ECG regularly and correct deficits.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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