Drug interactions
Azilsartan-chlorthalidone + Telmisartan
Severity: Major
Azilsartan-chlorthalidone and Telmisartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan duplicates the angiotensin receptor blockade already provided by azilsartan. Combined use increases hypotension, hyperkalemia and renal dysfunction without added benefit.
What this interaction means in plain words
Azilsartan-chlorthalidone and Telmisartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan-chlorthalidone belongs to Cardiovascular; Telmisartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II receptor blockade producing additive hypotensive, renal and potassium-retaining effects.
What to do
Avoid using two ARBs together and continue a single agent. If coadministered, monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Azilsartan-chlorthalidone
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Telmisartan?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Telmisartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Telmisartan duplicates the angiotensin receptor blockade already provided by azilsartan. Combined use increases hypotension, hyperkalemia and renal dysfunction without added benefit.
How serious is the interaction between Azilsartan-chlorthalidone and Telmisartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two ARBs together and continue a single agent. If coadministered, monitor blood pressure, creatinine and potassium.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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