Drug interactions
Azilsartan-chlorthalidone + Terbutaline
Severity: Moderate
Azilsartan-chlorthalidone and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline and chlorthalidone can each lower serum potassium, so combined use may cause significant hypokalemia, especially with high or repeated beta-agonist dosing. Hypokalemia increases arrhythmia risk. Azilsartan partly counteracts potassium loss.
What this interaction means in plain words
Azilsartan-chlorthalidone and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Additive hypokalemia from diuretic renal potassium loss and beta-2 agonist-driven intracellular potassium shift.
What to do
Monitor serum potassium and magnesium, particularly with high-dose or parenteral terbutaline. Replace potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Terbutaline
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Terbutaline?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbutaline and chlorthalidone can each lower serum potassium, so combined use may cause significant hypokalemia, especially with high or repeated beta-agonist dosing. Hypokalemia increases arrhythmia risk. Azilsartan partly counteracts potassium loss.
How serious is the interaction between Azilsartan-chlorthalidone and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly with high-dose or parenteral terbutaline. Replace potassium if low.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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