Drug interactions
Azithromycin + Betrixaban
Severity: Moderate
Azithromycin and Betrixaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin may inhibit P-glycoprotein and increase betrixaban exposure, raising bleeding risk. Betrixaban labeling advises dose reduction with P-gp inhibitors.
What this interaction means in plain words
Azithromycin and Betrixaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-glycoprotein inhibition reduces betrixaban efflux and increases its plasma concentrations.
What to do
Reduce the betrixaban dose as per labeling for P-gp inhibitors and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Betrixaban?
MediHelp rates the interaction as moderate. Azithromycin and Betrixaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azithromycin may inhibit P-glycoprotein and increase betrixaban exposure, raising bleeding risk. Betrixaban labeling advises dose reduction with P-gp inhibitors.
How serious is the interaction between Azithromycin and Betrixaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the betrixaban dose as per labeling for P-gp inhibitors and monitor for bleeding.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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