Drug interactions
Azithromycin + Cisapride
Severity: Contraindicated
Azithromycin and Cisapride: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and combined use increases the risk of torsades de pointes and sudden cardiac death. Cisapride labeling lists QT-prolonging drugs as contraindicated partners.
What this interaction means in plain words
Azithromycin and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azithromycin belongs to Anti Bacterial; Cisapride belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Do not co-administer; choose a non-QT-prolonging antibiotic or stop cisapride. Correct electrolytes and obtain an ECG if exposure has occurred.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
- Cisapride + Clarithromycin Contraindicated
Other interactions of Azithromycin
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
- Adagrasib + Azithromycin Major
Frequently asked questions
Can I take Azithromycin with Cisapride?
MediHelp rates the interaction as contraindicated. Azithromycin and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and combined use increases the risk of torsades de pointes and sudden cardiac death. Cisapride labeling lists QT-prolonging drugs as contraindicated partners.
How serious is the interaction between Azithromycin and Cisapride?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose a non-QT-prolonging antibiotic or stop cisapride. Correct electrolytes and obtain an ECG if exposure has occurred.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Ceritinib. The full list is on the Cisapride page.
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