Drug interactions
Azithromycin + Thioridazine
Severity: Contraindicated
Azithromycin and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine causes marked dose-related QT prolongation and is itself contraindicated with other QT-prolonging drugs. Adding azithromycin raises the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Azithromycin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azithromycin belongs to Anti Bacterial; Thioridazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through hERG potassium channel blockade.
What to do
Avoid the combination and choose a non-macrolide antibiotic with no QT effect. If unavoidable, use continuous ECG monitoring and keep electrolytes normal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Adagrasib + Azithromycin Major
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Thioridazine?
MediHelp rates the interaction as contraindicated. Azithromycin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes marked dose-related QT prolongation and is itself contraindicated with other QT-prolonging drugs. Adding azithromycin raises the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Azithromycin and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-macrolide antibiotic with no QT effect. If unavoidable, use continuous ECG monitoring and keep electrolytes normal.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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