Drug interactions
Azithromycin + Conjugated estrogens
Severity: Minor
Azithromycin and Conjugated estrogens: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been hypothesised to reduce estrogen recycling via gut flora, but evidence for a clinically relevant effect with azithromycin is lacking.
What this interaction means in plain words
Azithromycin and Conjugated estrogens have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of estrogen enterohepatic recirculation through altered gut flora; not established.
What to do
No action is generally needed; advise patients to report breakthrough bleeding or recurrence of symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Conjugated estrogens?
MediHelp rates the interaction as minor. Azithromycin and Conjugated estrogens have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been hypothesised to reduce estrogen recycling via gut flora, but evidence for a clinically relevant effect with azithromycin is lacking.
How serious is the interaction between Azithromycin and Conjugated estrogens?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed; advise patients to report breakthrough bleeding or recurrence of symptoms.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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