Drug interactions
Azithromycin + Dichlorphenamide
Severity: Moderate
Azithromycin and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide commonly causes hypokalemia, which is a risk factor for QT-related arrhythmia when combined with a QT-prolonging drug such as azithromycin. Azithromycin itself does not clearly lower potassium, so the concern is mainly an indirect arrhythmia risk.
What this interaction means in plain words
Azithromycin and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Dichlorphenamide-induced hypokalemia may potentiate azithromycin's QT prolongation.
What to do
Check serum potassium and correct deficits before and during azithromycin therapy. Obtain an ECG if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Azithromycin with Dichlorphenamide?
MediHelp rates the interaction as moderate. Azithromycin and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide commonly causes hypokalemia, which is a risk factor for QT-related arrhythmia when combined with a QT-prolonging drug such as azithromycin. Azithromycin itself does not clearly lower potassium, so the concern is mainly an indirect arrhythmia risk.
How serious is the interaction between Azithromycin and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and correct deficits before and during azithromycin therapy. Obtain an ECG if the patient has other QT risk factors.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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