Drug interactions
Azithromycin + Glecaprevir / pibrentasvir
Severity: Minor
Azithromycin and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both glecaprevir and pibrentasvir are P-glycoprotein substrates, and azithromycin may mildly inhibit this transporter. Exposure could rise somewhat, though a meaningful clinical effect is not well documented.
What this interaction means in plain words
Azithromycin and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of P-glycoprotein efflux by azithromycin.
What to do
No dose adjustment is usually needed. Monitor for increased adverse effects such as headache or gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Azithromycin and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both glecaprevir and pibrentasvir are P-glycoprotein substrates, and azithromycin may mildly inhibit this transporter. Exposure could rise somewhat, though a meaningful clinical effect is not well documented.
How serious is the interaction between Azithromycin and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for increased adverse effects such as headache or gastrointestinal upset.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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