Drug interactions
Azithromycin + Indacaterol inhaled
Severity: Moderate
Azithromycin and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta2 agonists can cause tachycardia, hypokalemia and QT lengthening, and azithromycin also has QT-prolonging potential. Together they may raise the risk of ventricular arrhythmias, mainly in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Azithromycin and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization, with beta2-agonist-induced hypokalemia adding to the risk.
What to do
Check potassium and use an ECG in patients with cardiac risk factors. Counsel patients to report palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Azithromycin and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta2 agonists can cause tachycardia, hypokalemia and QT lengthening, and azithromycin also has QT-prolonging potential. Together they may raise the risk of ventricular arrhythmias, mainly in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Azithromycin and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and use an ECG in patients with cardiac risk factors. Counsel patients to report palpitations or syncope.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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