Drug interactions
Azithromycin + Indapamide
Severity: Major
Azithromycin and Indapamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and indapamide may cause hypokalemia and hypomagnesemia that further raise arrhythmia risk. Torsades de pointes is the concern.
What this interaction means in plain words
Azithromycin and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azithromycin belongs to Anti Bacterial; Indapamide belongs to Cardiovascular.
Why it happens
Additive QT prolongation, aggravated by diuretic-induced electrolyte depletion.
What to do
Check and correct potassium and magnesium before and during therapy, and obtain an ECG in patients with other risk factors; consider an alternative antibiotic if risk is high.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Indapamide
Frequently asked questions
Can I take Azithromycin with Indapamide?
MediHelp rates the interaction as major. Azithromycin and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and indapamide may cause hypokalemia and hypomagnesemia that further raise arrhythmia risk. Torsades de pointes is the concern.
How serious is the interaction between Azithromycin and Indapamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during therapy, and obtain an ECG in patients with other risk factors; consider an alternative antibiotic if risk is high.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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