Drug interactions
Azithromycin + Lofepramine
Severity: Moderate
Azithromycin and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as lofepramine can slow cardiac conduction and prolong QT, and azithromycin adds further QT risk. The combination may increase the chance of ventricular arrhythmia, especially with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Azithromycin and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization and conduction.
What to do
Consider an ECG and check electrolytes before and during the combination. Use an alternative antibiotic if QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Lofepramine?
MediHelp rates the interaction as moderate. Azithromycin and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants such as lofepramine can slow cardiac conduction and prolong QT, and azithromycin adds further QT risk. The combination may increase the chance of ventricular arrhythmia, especially with cardiac disease or electrolyte disturbance.
How serious is the interaction between Azithromycin and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG and check electrolytes before and during the combination. Use an alternative antibiotic if QT risk factors are present.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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