Drug interactions
Azithromycin + Octreotide
Severity: Moderate
Azithromycin and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and azithromycin adds to the QT effect. The combination may modestly increase arrhythmia risk in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Azithromycin and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Octreotide belongs to Endocrine.
Why it happens
Additive QT prolongation, with octreotide-induced bradycardia increasing susceptibility to torsades de pointes.
What to do
Check an ECG and electrolytes at baseline in at-risk patients and monitor heart rate and QTc during combined use. Consider a different antibiotic if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Azithromycin with Octreotide?
MediHelp rates the interaction as moderate. Azithromycin and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and azithromycin adds to the QT effect. The combination may modestly increase arrhythmia risk in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Azithromycin and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes at baseline in at-risk patients and monitor heart rate and QTc during combined use. Consider a different antibiotic if the QTc is prolonged.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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