Drug interactions
Azithromycin + Romidepsin
Severity: Moderate
Azithromycin and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause QT changes and is a P-glycoprotein substrate, while azithromycin has QT-prolonging and weak P-glycoprotein inhibiting properties. The combination may increase both arrhythmia risk and romidepsin exposure.
What this interaction means in plain words
Azithromycin and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and possible P-glycoprotein inhibition increasing romidepsin levels.
What to do
Check ECG and correct potassium and magnesium before each romidepsin cycle. Consider an alternative antibiotic if QT risk is substantial.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Romidepsin?
MediHelp rates the interaction as moderate. Azithromycin and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin can cause QT changes and is a P-glycoprotein substrate, while azithromycin has QT-prolonging and weak P-glycoprotein inhibiting properties. The combination may increase both arrhythmia risk and romidepsin exposure.
How serious is the interaction between Azithromycin and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before each romidepsin cycle. Consider an alternative antibiotic if QT risk is substantial.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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