Drug interactions
Azithromycin + Thiothixene
Severity: Moderate
Azithromycin and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin and the antipsychotic thiothixene may each prolong the QT interval, so combining them may increase the risk of ventricular arrhythmia including torsades de pointes.
What this interaction means in plain words
Azithromycin and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Prefer a non-QT-prolonging antibiotic when possible. If combined, check baseline ECG and electrolytes and monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Thiothixene?
MediHelp rates the interaction as moderate. Azithromycin and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azithromycin and the antipsychotic thiothixene may each prolong the QT interval, so combining them may increase the risk of ventricular arrhythmia including torsades de pointes.
How serious is the interaction between Azithromycin and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging antibiotic when possible. If combined, check baseline ECG and electrolytes and monitor for palpitations or syncope.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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