Drug interactions
Azithromycin + Tobramycin inhaled
Severity: Minor
Azithromycin and Tobramycin inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin has rarely been associated with hearing loss, and tobramycin is ototoxic and nephrotoxic, though inhaled systemic exposure is low. A meaningful additive effect is plausible but not well documented, and the combination is commonly used in cystic fibrosis.
What this interaction means in plain words
Azithromycin and Tobramycin inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive ototoxicity; inhaled tobramycin has low systemic absorption.
What to do
Ask about hearing loss, tinnitus or balance problems and monitor renal function, particularly with prolonged therapy or renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Tobramycin inhaled?
MediHelp rates the interaction as minor. Azithromycin and Tobramycin inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azithromycin has rarely been associated with hearing loss, and tobramycin is ototoxic and nephrotoxic, though inhaled systemic exposure is low. A meaningful additive effect is plausible but not well documented, and the combination is commonly used in cystic fibrosis.
How serious is the interaction between Azithromycin and Tobramycin inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about hearing loss, tinnitus or balance problems and monitor renal function, particularly with prolonged therapy or renal impairment.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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