Drug interactions
Azithromycin + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Azithromycin and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin has QT-prolonging potential and vilanterol, a long-acting beta-agonist, can add to cardiac effects such as tachycardia and QT changes. The combined effect on arrhythmia risk is generally small but matters in patients with heart disease.
What this interaction means in plain words
Azithromycin and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and beta-adrenergic stimulation.
What to do
In patients with QT risk factors consider a non-macrolide antibiotic. Otherwise correct electrolytes and monitor heart rate, palpitations and ECG as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Azithromycin and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azithromycin has QT-prolonging potential and vilanterol, a long-acting beta-agonist, can add to cardiac effects such as tachycardia and QT changes. The combined effect on arrhythmia risk is generally small but matters in patients with heart disease.
How serious is the interaction between Azithromycin and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients with QT risk factors consider a non-macrolide antibiotic. Otherwise correct electrolytes and monitor heart rate, palpitations and ECG as needed.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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