Drug interactions
Baclofen + Buprenorphine
Severity: Moderate
Baclofen and Buprenorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and combined use can cause marked sedation, weakness and respiratory depression. Risk rises with higher doses, renal impairment and older age.
What this interaction means in plain words
Baclofen and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Buprenorphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and GABA-B agonism.
What to do
Use the lowest effective doses and monitor sedation and respiratory function, especially at initiation. Reduce baclofen dose in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Buprenorphine?
MediHelp rates the interaction as moderate. Baclofen and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and combined use can cause marked sedation, weakness and respiratory depression. Risk rises with higher doses, renal impairment and older age.
How serious is the interaction between Baclofen and Buprenorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory function, especially at initiation. Reduce baclofen dose in renal impairment.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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