Drug interactions
Baclofen + Butorphanol
Severity: Moderate
Baclofen and Butorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baclofen is a CNS depressant and together with an opioid can cause marked drowsiness, weakness and respiratory depression. Risk is higher with renal impairment, which increases baclofen accumulation.
What this interaction means in plain words
Baclofen and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Butorphanol belongs to Musculoskeletal.
Why it happens
Additive CNS depression through opioid receptor activation and GABA-B agonism.
What to do
Use the lowest effective doses and monitor sedation and respiratory status. Reduce baclofen dose in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Butorphanol?
MediHelp rates the interaction as moderate. Baclofen and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Baclofen is a CNS depressant and together with an opioid can cause marked drowsiness, weakness and respiratory depression. Risk is higher with renal impairment, which increases baclofen accumulation.
How serious is the interaction between Baclofen and Butorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory status. Reduce baclofen dose in renal impairment.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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