Drug interactions
Baclofen + Clemastine
Severity: Moderate
Baclofen and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a first-generation antihistamine that commonly causes sedation. Taken with baclofen, drowsiness and reduced coordination may be intensified.
What this interaction means in plain words
Baclofen and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Clemastine belongs to Respiratory.
Why it happens
Additive CNS depression from H1-receptor antagonism and GABA-B agonism.
What to do
Advise against driving and hazardous tasks until tolerance is known. Consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Clemastine
Frequently asked questions
Can I take Baclofen with Clemastine?
MediHelp rates the interaction as moderate. Baclofen and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a first-generation antihistamine that commonly causes sedation. Taken with baclofen, drowsiness and reduced coordination may be intensified.
How serious is the interaction between Baclofen and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against driving and hazardous tasks until tolerance is known. Consider a non-sedating antihistamine.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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