Drug interactions
Baclofen + Esketamine
Severity: Moderate
Baclofen and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baclofen causes sedation, weakness and, in overdose or at high doses, respiratory depression. With esketamine, additive CNS depression and impaired alertness may occur.
What this interaction means in plain words
Baclofen and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-B agonism and NMDA antagonism.
What to do
Monitor sedation and respiratory status during esketamine sessions, and use the lowest effective baclofen dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Esketamine?
MediHelp rates the interaction as moderate. Baclofen and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Baclofen causes sedation, weakness and, in overdose or at high doses, respiratory depression. With esketamine, additive CNS depression and impaired alertness may occur.
How serious is the interaction between Baclofen and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status during esketamine sessions, and use the lowest effective baclofen dose.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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