Drug interactions
Baclofen + Fentanyl
Severity: Moderate
Baclofen and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baclofen is a GABA-B agonist muscle relaxant that adds to fentanyl's sedation and respiratory depression. Hypotension and confusion may occur.
What this interaction means in plain words
Baclofen and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Fentanyl belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression.
What to do
Use the lowest effective doses and monitor sedation and respiration, particularly in elderly or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Fentanyl?
MediHelp rates the interaction as moderate. Baclofen and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Baclofen is a GABA-B agonist muscle relaxant that adds to fentanyl's sedation and respiratory depression. Hypotension and confusion may occur.
How serious is the interaction between Baclofen and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiration, particularly in elderly or renally impaired patients.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Full monographs, dosing and an interaction checker in the MediHelp app
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