Drug interactions
Baclofen + Flurazepam
Severity: Moderate
Baclofen and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause more drowsiness, dizziness, impaired coordination and slowed psychomotor performance. Falls and next-day impairment are a particular concern, because flurazepam's active metabolite has a long half-life, especially in older adults.
What this interaction means in plain words
Baclofen and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-B agonism (baclofen) and GABA-A positive modulation (flurazepam).
What to do
Start with the lowest effective doses and titrate slowly, and counsel patients about driving and operating machinery. Monitor older or frail patients for sedation, confusion and falls, and consider reducing the benzodiazepine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Flurazepam?
MediHelp rates the interaction as moderate. Baclofen and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause more drowsiness, dizziness, impaired coordination and slowed psychomotor performance. Falls and next-day impairment are a particular concern, because flurazepam's active metabolite has a long half-life, especially in older adults.
How serious is the interaction between Baclofen and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and titrate slowly, and counsel patients about driving and operating machinery. Monitor older or frail patients for sedation, confusion and falls, and consider reducing the benzodiazepine dose.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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