Drug interactions
Baclofen + Levorphanol
Severity: Major
Baclofen and Levorphanol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is a potent opioid and baclofen is a CNS depressant, so combined use can cause profound sedation, respiratory depression, hypotension and, in severe cases, coma. The risk is highest at higher doses, in opioid-naive patients and in the elderly.
What this interaction means in plain words
Baclofen and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism and GABA-B agonism.
What to do
Use the lowest effective doses for the shortest time and monitor respiratory rate and level of sedation, particularly after dose changes. Counsel patients to avoid alcohol and other sedatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Levorphanol?
MediHelp rates the interaction as major. Baclofen and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levorphanol is a potent opioid and baclofen is a CNS depressant, so combined use can cause profound sedation, respiratory depression, hypotension and, in severe cases, coma. The risk is highest at higher doses, in opioid-naive patients and in the elderly.
How serious is the interaction between Baclofen and Levorphanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and monitor respiratory rate and level of sedation, particularly after dose changes. Counsel patients to avoid alcohol and other sedatives.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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