Drug interactions
Baclofen + Meprobamate
Severity: Moderate
Baclofen and Meprobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic with a barbiturate-like profile, and baclofen adds to its CNS depression. The combination can cause marked drowsiness, impaired coordination and falls.
What this interaction means in plain words
Baclofen and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; meprobamate acts at GABA-A receptors and baclofen at GABA-B receptors.
What to do
Use the lowest effective doses and advise patients to avoid alcohol and driving. Monitor older patients for sedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Meprobamate?
MediHelp rates the interaction as moderate. Baclofen and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative-anxiolytic with a barbiturate-like profile, and baclofen adds to its CNS depression. The combination can cause marked drowsiness, impaired coordination and falls.
How serious is the interaction between Baclofen and Meprobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and advise patients to avoid alcohol and driving. Monitor older patients for sedation and falls.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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