Drug interactions
Baclofen + Metoclopramide intranasal
Severity: Moderate
Baclofen and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause extrapyramidal effects, drowsiness and other CNS adverse effects, and baclofen can add to sedation and may antagonize some of metoclopramide's dopamine-related effects. The interaction is not well characterized.
What this interaction means in plain words
Baclofen and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Likely additive CNS effects; a specific mechanism is not firmly established.
What to do
Monitor for excessive drowsiness, dizziness and movement disorders. Prefer another antiemetic if the patient cannot tolerate the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Baclofen and Metoclopramide intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Baclofen and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause extrapyramidal effects, drowsiness and other CNS adverse effects, and baclofen can add to sedation and may antagonize some of metoclopramide's dopamine-related effects. The interaction is not well characterized.
How serious is the interaction between Baclofen and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness, dizziness and movement disorders. Prefer another antiemetic if the patient cannot tolerate the combination.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
