Drug interactions
Baclofen + Orphenadrine
Severity: Moderate
Baclofen and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are muscle relaxants with CNS effects, and orphenadrine also has anticholinergic activity. Together they can cause marked drowsiness, dizziness, confusion and weakness, especially in older adults.
What this interaction means in plain words
Baclofen and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with added anticholinergic effects from orphenadrine.
What to do
Avoid combining in older patients where possible, and otherwise use the lowest effective doses. Monitor for sedation, confusion, urinary retention and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Orphenadrine?
MediHelp rates the interaction as moderate. Baclofen and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are muscle relaxants with CNS effects, and orphenadrine also has anticholinergic activity. Together they can cause marked drowsiness, dizziness, confusion and weakness, especially in older adults.
How serious is the interaction between Baclofen and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining in older patients where possible, and otherwise use the lowest effective doses. Monitor for sedation, confusion, urinary retention and falls.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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