Drug interactions
Baclofen + Papaveretum
Severity: Major
Baclofen and Papaveretum: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine, so with baclofen there is a risk of profound sedation, respiratory depression, hypotension and coma.
What this interaction means in plain words
Baclofen and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism and GABA-B agonism.
What to do
Use the lowest effective doses and monitor respiratory rate and sedation closely, particularly after dose changes. Reduce the dose of one or both agents if drowsiness is marked.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Papaveretum?
MediHelp rates the interaction as major. Baclofen and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum contains opium alkaloids including morphine, so with baclofen there is a risk of profound sedation, respiratory depression, hypotension and coma.
How serious is the interaction between Baclofen and Papaveretum?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor respiratory rate and sedation closely, particularly after dose changes. Reduce the dose of one or both agents if drowsiness is marked.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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