Drug interactions
Baclofen + Triclofos
Severity: Moderate
Baclofen and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic that is converted to trichloroethanol, and combining it with baclofen can increase sedation and impair alertness. Additive respiratory depression is possible at higher doses or in vulnerable patients.
What this interaction means in plain words
Baclofen and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; trichloroethanol enhances GABA-A activity while baclofen acts at GABA-B receptors.
What to do
Monitor for oversedation and reduced respiratory effort, and use the lowest effective doses. Avoid alcohol and other sedating drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Triclofos?
MediHelp rates the interaction as moderate. Baclofen and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic that is converted to trichloroethanol, and combining it with baclofen can increase sedation and impair alertness. Additive respiratory depression is possible at higher doses or in vulnerable patients.
How serious is the interaction between Baclofen and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduced respiratory effort, and use the lowest effective doses. Avoid alcohol and other sedating drugs.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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