Drug interactions
Baricitinib + Etrasimod
Severity: Major
Baricitinib and Etrasimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immune function, so using them together may add to the risk of serious infection. Etrasimod lowers circulating lymphocytes and its effect persists for weeks after the last dose. The combination has not been studied.
What this interaction means in plain words
Baricitinib and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baricitinib belongs to Musculoskeletal; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression through JAK inhibition and S1P receptor modulation with lymphocyte sequestration.
What to do
Avoid concurrent use and for several weeks after stopping etrasimod. If unavoidable, monitor closely for infection and check lymphocyte counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Baricitinib with Etrasimod?
MediHelp rates the interaction as major. Baricitinib and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune function, so using them together may add to the risk of serious infection. Etrasimod lowers circulating lymphocytes and its effect persists for weeks after the last dose. The combination has not been studied.
How serious is the interaction between Baricitinib and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and for several weeks after stopping etrasimod. If unavoidable, monitor closely for infection and check lymphocyte counts.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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