Drug interactions
Baricitinib + Hydrochlorothiazide-valsartan
Severity: Minor
Baricitinib and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baricitinib is eliminated partly by OAT3, and labeling advises against strong OAT3 inhibitors such as probenecid. Valsartan is not recognized as a strong OAT3 inhibitor, so a clinically meaningful rise in baricitinib exposure is unlikely.
What this interaction means in plain words
Baricitinib and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Possible weak OAT3 inhibition by valsartan reducing baricitinib renal elimination; clinical relevance is unproven.
What to do
No dose adjustment is generally needed. Monitor for baricitinib adverse effects such as infection and cytopenias as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Baricitinib and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Baricitinib is eliminated partly by OAT3, and labeling advises against strong OAT3 inhibitors such as probenecid. Valsartan is not recognized as a strong OAT3 inhibitor, so a clinically meaningful rise in baricitinib exposure is unlikely.
How serious is the interaction between Baricitinib and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for baricitinib adverse effects such as infection and cytopenias as usual.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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