Drug interactions
Baricitinib + Ifosfamide
Severity: Major
Baricitinib and Ifosfamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide causes myelosuppression and baricitinib suppresses immune signaling, so together they may increase the risk of serious infection. The combination is pharmacodynamic and is relevant in patients receiving chemotherapy.
What this interaction means in plain words
Baricitinib and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baricitinib belongs to Musculoskeletal; Ifosfamide belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression.
What to do
Avoid combining where possible and hold baricitinib during myelosuppressive chemotherapy if feasible. Monitor blood counts and for signs of infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Baricitinib with Ifosfamide?
MediHelp rates the interaction as major. Baricitinib and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ifosfamide causes myelosuppression and baricitinib suppresses immune signaling, so together they may increase the risk of serious infection. The combination is pharmacodynamic and is relevant in patients receiving chemotherapy.
How serious is the interaction between Baricitinib and Ifosfamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and hold baricitinib during myelosuppressive chemotherapy if feasible. Monitor blood counts and for signs of infection.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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