Drug interactions
Baricitinib + Meclofenamic acid
Severity: Minor
Baricitinib and Meclofenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baricitinib is eliminated partly through renal OAT3-mediated transport. Meclofenamate may compete for this pathway, but it is not a recognized strong OAT3 inhibitor like probenecid, so any increase in baricitinib exposure is probably small.
What this interaction means in plain words
Baricitinib and Meclofenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Possible competition for OAT3-mediated renal tubular secretion of baricitinib.
What to do
No dose change is generally needed. Monitor for baricitinib adverse effects such as infection and cytopenias, and for renal function with concurrent NSAID use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Meclofenamic acid?
MediHelp rates the interaction as minor. Baricitinib and Meclofenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Baricitinib is eliminated partly through renal OAT3-mediated transport. Meclofenamate may compete for this pathway, but it is not a recognized strong OAT3 inhibitor like probenecid, so any increase in baricitinib exposure is probably small.
How serious is the interaction between Baricitinib and Meclofenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for baricitinib adverse effects such as infection and cytopenias, and for renal function with concurrent NSAID use.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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