Drug interactions
Baricitinib + Metformin-pioglitazone
Severity: Minor
Baricitinib and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is not a recognized clinically relevant OAT3 inhibitor, so no meaningful increase in baricitinib exposure is expected. The legacy alert is not supported by labeling.
What this interaction means in plain words
Baricitinib and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Metformin-pioglitazone belongs to Endocrine.
Why it happens
No established mechanism; pioglitazone is not a clinically significant OAT3 inhibitor.
What to do
No dose adjustment is needed. Monitor for baricitinib adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Baricitinib and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone is not a recognized clinically relevant OAT3 inhibitor, so no meaningful increase in baricitinib exposure is expected. The legacy alert is not supported by labeling.
How serious is the interaction between Baricitinib and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for baricitinib adverse effects as usual.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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