Drug interactions
Baricitinib + Pimecrolimus
Severity: Minor
Baricitinib and Pimecrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimecrolimus is a topical calcineurin inhibitor with minimal systemic absorption, so additive systemic immunosuppression with oral baricitinib is unlikely in most patients. Risk may rise only with extensive application on damaged skin.
What this interaction means in plain words
Baricitinib and Pimecrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Pimecrolimus belongs to Miscellaneous.
Why it happens
Potential additive immunosuppression, limited by low systemic exposure to topical pimecrolimus.
What to do
Use pimecrolimus on limited skin areas and monitor for skin or systemic infection. No dose change is routinely required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Pimecrolimus
Frequently asked questions
Can I take Baricitinib with Pimecrolimus?
MediHelp rates the interaction as minor. Baricitinib and Pimecrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pimecrolimus is a topical calcineurin inhibitor with minimal systemic absorption, so additive systemic immunosuppression with oral baricitinib is unlikely in most patients. Risk may rise only with extensive application on damaged skin.
How serious is the interaction between Baricitinib and Pimecrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use pimecrolimus on limited skin areas and monitor for skin or systemic infection. No dose change is routinely required.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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