Drug interactions
Pimecrolimus + Procarbazine
Severity: Minor
Pimecrolimus and Procarbazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is myelosuppressive and immunosuppressive, while pimecrolimus is a topical calcineurin inhibitor with minimal systemic absorption. Clinically meaningful additive immunosuppression is unlikely with topical use.
What this interaction means in plain words
Pimecrolimus and Procarbazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pimecrolimus belongs to Miscellaneous; Procarbazine belongs to Oncology.
Why it happens
Theoretical additive immunosuppression, limited by minimal systemic absorption of topical pimecrolimus.
What to do
Apply pimecrolimus only to limited skin areas and avoid it on broken or infected skin during chemotherapy. Monitor for skin infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Pimecrolimus
Frequently asked questions
Can I take Pimecrolimus with Procarbazine?
MediHelp rates the interaction as minor. Pimecrolimus and Procarbazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Procarbazine is myelosuppressive and immunosuppressive, while pimecrolimus is a topical calcineurin inhibitor with minimal systemic absorption. Clinically meaningful additive immunosuppression is unlikely with topical use.
How serious is the interaction between Pimecrolimus and Procarbazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Apply pimecrolimus only to limited skin areas and avoid it on broken or infected skin during chemotherapy. Monitor for skin infection.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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