Drug interactions
Baricitinib + Pioglitazone
Severity: Minor
Baricitinib and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is not a recognized strong OAT3 inhibitor, and no clinically meaningful effect on baricitinib exposure has been established. Any interaction is theoretical.
What this interaction means in plain words
Baricitinib and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Pioglitazone belongs to Endocrine.
Why it happens
Theoretical weak OAT3 inhibition reducing baricitinib renal clearance.
What to do
No dose adjustment is needed. Monitor for baricitinib adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Pioglitazone
Frequently asked questions
Can I take Baricitinib with Pioglitazone?
MediHelp rates the interaction as minor. Baricitinib and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone is not a recognized strong OAT3 inhibitor, and no clinically meaningful effect on baricitinib exposure has been established. Any interaction is theoretical.
How serious is the interaction between Baricitinib and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for baricitinib adverse effects as usual.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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