Drug interactions
Baricitinib + Trastuzumab
Severity: Moderate
Baricitinib and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baricitinib is immunosuppressive and trastuzumab is usually given with myelosuppressive chemotherapy, so infection risk may rise. Trastuzumab alone has limited immunosuppressive activity.
What this interaction means in plain words
Baricitinib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Trastuzumab belongs to Oncology.
Why it happens
Additive immunosuppressive and hematologic effects; no pharmacokinetic interaction is established.
What to do
Monitor neutrophil and lymphocyte counts and for infection. Reassess the need for baricitinib during cancer treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Baricitinib with Trastuzumab?
MediHelp rates the interaction as moderate. Baricitinib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Baricitinib is immunosuppressive and trastuzumab is usually given with myelosuppressive chemotherapy, so infection risk may rise. Trastuzumab alone has limited immunosuppressive activity.
How serious is the interaction between Baricitinib and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil and lymphocyte counts and for infection. Reassess the need for baricitinib during cancer treatment.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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