Drug interactions
Basiliximab + Canakinumab
Severity: Major
Basiliximab and Canakinumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canakinumab blocks IL-1 beta and is associated with serious infections. With basiliximab, overall immunosuppression and infection risk may be increased.
What this interaction means in plain words
Basiliximab and Canakinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Basiliximab belongs to Miscellaneous; Canakinumab belongs to Miscellaneous.
Why it happens
Additive immunosuppression through IL-1 beta neutralization and IL-2 receptor blockade.
What to do
Avoid combining where possible; if both are needed, monitor closely for infection and withhold canakinumab during serious infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Other interactions of Canakinumab
- Adalimumab + Canakinumab Major
- Anakinra + Canakinumab Major
- Baricitinib + Canakinumab Major
- Canakinumab + Etanercept Major
- Canakinumab + Golimumab Major
- Canakinumab + Infliximab Major
Frequently asked questions
Can I take Basiliximab with Canakinumab?
MediHelp rates the interaction as major. Basiliximab and Canakinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Canakinumab blocks IL-1 beta and is associated with serious infections. With basiliximab, overall immunosuppression and infection risk may be increased.
How serious is the interaction between Basiliximab and Canakinumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if both are needed, monitor closely for infection and withhold canakinumab during serious infection.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
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