Drug interactions
Canakinumab + Golimumab
Severity: Major
Canakinumab and Golimumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canakinumab blocks IL-1 beta and golimumab blocks TNF, both of which are important for host defence. Used together they raise the risk of serious infection. Labeling for IL-1 blockers advises against combination with TNF inhibitors.
What this interaction means in plain words
Canakinumab and Golimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Canakinumab belongs to Miscellaneous; Golimumab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression through IL-1 beta and TNF blockade.
What to do
Avoid concurrent use and choose one agent. If combined, monitor closely for infection and stop at the first serious infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Canakinumab
- Adalimumab + Canakinumab Major
- Anakinra + Canakinumab Major
- Baricitinib + Canakinumab Major
- Basiliximab + Canakinumab Major
- Canakinumab + Etanercept Major
- Canakinumab + Infliximab Major
Frequently asked questions
Can I take Canakinumab with Golimumab?
MediHelp rates the interaction as major. Canakinumab and Golimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Canakinumab blocks IL-1 beta and golimumab blocks TNF, both of which are important for host defence. Used together they raise the risk of serious infection. Labeling for IL-1 blockers advises against combination with TNF inhibitors.
How serious is the interaction between Canakinumab and Golimumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose one agent. If combined, monitor closely for infection and stop at the first serious infection.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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