Drug interactions
Basiliximab + Siponimod
Severity: Moderate
Basiliximab and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Basiliximab blocks IL-2 receptor mediated T-cell activation, and siponimod reduces circulating lymphocytes, so the combined effect on immune defence is additive. Infection risk may be higher than with either drug alone.
What this interaction means in plain words
Basiliximab and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Basiliximab belongs to Miscellaneous; Siponimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression from IL-2 receptor blockade and S1P receptor mediated lymphocyte sequestration.
What to do
Monitor lymphocyte counts and signs of infection, and avoid starting siponimod during the active effect of basiliximab unless essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Basiliximab with Siponimod?
MediHelp rates the interaction as moderate. Basiliximab and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Basiliximab blocks IL-2 receptor mediated T-cell activation, and siponimod reduces circulating lymphocytes, so the combined effect on immune defence is additive. Infection risk may be higher than with either drug alone.
How serious is the interaction between Basiliximab and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lymphocyte counts and signs of infection, and avoid starting siponimod during the active effect of basiliximab unless essential.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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