Drug interactions
Bazedoxifene / conjugated estrogens + Cimetidine
Severity: Minor
Bazedoxifene / conjugated estrogens and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a weak CYP3A4 inhibitor and may modestly increase estrogen and bazedoxifene exposure. The effect is generally small.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cimetidine weakly inhibits CYP3A4-mediated metabolism of the estrogen and bazedoxifene components.
What to do
No dose change is usually needed; monitor for estrogenic adverse effects such as breast tenderness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bazedoxifene / conjugated estrogens and Cimetidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Cimetidine?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine is a weak CYP3A4 inhibitor and may modestly increase estrogen and bazedoxifene exposure. The effect is generally small.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for estrogenic adverse effects such as breast tenderness.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
